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KMID : 0359920070260030320
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Korean Journal of Nephrology
2007 Volume.26 No. 3 p.320 ~ p.326
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Vitamin D Receptor Genotype is Associated with Secondary Hyperparathyroidism in Hemodialysis Patients
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Yoon Su-In
Oh Tae-Geun
Kwon Soon-Kil
Kim Hye-Young
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Abstract
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Purpose : It is known that secondary hyperparathyroidism in end stage renal disease (ESRD) patients is associated with vitamin D receptor (VDR) gene polymorphism, but there is no consensus on its genotype. There is lack of data in Ca, P, calcitriol and VDR polymorphism.
Methods : We measured serum Ca, P, alkaline phosphatase, parathyroid hormone (PTH), and 1,25 (OH)2D3 of the 53 hemodialysis patients. The genotypes of VDR were classified BB, Bb, bb according to restriction patterns in PCR of the patients’ DNA using Bsm I restriction enzyme.
Results : The patients with BB, Bb, bb type were 0 (0%), 15 (28.3%), 38 (71.7%) respectively. Serum PTH levels were 70.0±63.3 pg/mL and 146.9±184.9 pg/mL in Bb, bb type respectively, and showed significant statistical difference (p<0.05). Serum 1,25 (OH)2D3 levels were 7.68±3.41 pg/mL and 6.59 ±2.67 pg/mL in Bb and bb genotype respectively without statistical significance. And there was no significant statistical differences among the serum levels of calcium, phosphorus, alkaline phosphatase.
Conclusion : Vitamin D receptor gene polymorphism is associated with secondary hyperparathyroidism in hemodialysis patients, and the b allelle is suggestive of poorer bone mineral metabolism.
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KEYWORD
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Hyperparathyroidism, Receptors Calcitriol, Polymorphism Genetic, Renal dialysis
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